Abcam, ab8295, Anti-Cardiac Troponin T antibody [1C11]

Size: 200µg
Anti-Cardiac Troponin T antibody [1C11] (ab8295) is a mouse monoclonal antibody detecting Cardiac Troponin T in IHC-P, ICC/IF, ELISA . Suitable for Dog, Human, Mouse, Rat . - Over 280 publications - Trusted since 2001
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:1C11,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Rat, Mouse, Dog, Human,
Applications:IHC-P, ICC/IF, sELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human TNNT2.P45379,
Specificity:This antibody detects Troponin T in human cardiac muscle. No cross-reaction with skeletal troponin T, cTnI and TnC.

Product details:
Anti-Cardiac Troponin T antibody [1C11] (ab8295) is a mouse monoclonal antibody and is validated for use in ICC/IF, IHC-P and sELISA.
Abcam's high quality validation processes ensure Anti-Cardiac Troponin T antibody [1C11] (ab8295) has high sensitivity and specificity.
Anti-Cardiac Troponin T antibody [1C11] (ab8295) has 14 independent reviews from customers.
Anti-Cardiac Troponin T antibody [1C11] (ab8295) specifically detects Cardiac Troponin T (UniProt ID: P45379; Molecular weight: 36kDa) and is sold in 200 µg selling sizes.
One of the top cited clones for this target with >350 citations. Cardiac Troponin T is a crucial key biomarker for myocardial infarction and heart failure, regulating muscle contraction and myofibril formation. Mutations in Cardiac Troponin T are linked to familial hypertrophic cardiomyopathy and dilated cardiomyopathy, with various isoforms expressed in the human heart. This antibody is a ket tool in acute coronary syndrome research, particularly in understanding Troponin T levels and heart attack diagnosis. It is widely used in studies of Cardiac Troponin T assays and cardiac-specific troponin

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Purification notes-Purified from TCS, Storage buffer-pH: 7.4Preservative: 0.1% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Cardiac Troponin T also known as cTnT or cardiac T plays an important role in muscle contraction. As a component of the troponin complex it binds to tropomyosin and facilitates the actin-myosin interaction in cardiac muscle fibers. cTnT has a molecular mass of approximately 39 kDa and is expressed mainly in cardiac tissue. Researchers identify it through various antibodies such as 1C11 and 1F11 ensuring precise detection and analysis.
Biological function summary
Cardiac troponin T is integral to the regulation of cardiac muscle contraction. It forms part of the troponin complex which also includes troponin I and troponin C and is involved in calcium-mediated control of cardiac muscle contraction. The presence of cTnT influences the interaction of actin and myosin essential for heart muscle contraction and relaxation. This ensures efficient cardiac function and response to physiological demands.
Pathways
Cardiac troponin T functions in the excitation-contraction coupling and the sarcomere organization pathways. Its role in these pathways establishes connections between electrical signals and mechanical contraction. It interacts closely with troponin I and troponin C facilitating the transmission of calcium's signal for cardiac muscle contraction. Proper function within these pathways is important for maintaining heart rhythm and muscle strength.
Cardiac troponin T serves as a biomarker for cardiovascular conditions. Elevated levels in the blood indicate myocardial infarction or acute coronary syndrome providing vital information for diagnosis and management. Alterations in the expression of cTnT can also be associated with cardiomyopathies where it might interact with other cardiac proteins during disease progression. The study of anti-cardiac troponin antibodies including anti T aids in understanding these conditions and developing therapeutic strategies.