Abcam, ab85051, Anti-BTG2/PC3 antibody

Size: 100µg
Rabbit Polyclonal BTG2/PC3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Synthetic Peptide within Human BTG2.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BTG2. The exact immunogen used to generate this antibody is proprietary information.P78543

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
BTG2 also known as PC3 is a protein encoded by the BTG2 gene. The protein has a molecular weight of approximately 18-20 kDa. It mainly functions as a tumor suppressor and is involved in the regulation of the cell cycle. This protein modulates the transcriptional activity of genes associated with cell growth and differentiation. BTG2 is broadly expressed in various tissues including the brain liver and spleen where it contributes to maintaining normal cellular functions.
Biological function summary
The BTG2 protein plays an important role in controlling cell cycle progression and apoptosis. It negatively regulates the transition from the G1 phase to the S phase of the cell cycle by interacting with cyclin D1 and E2F-1 transcription factors which are critical for DNA synthesis initiation. Additionally BTG2 does not operate as part of a larger protein complex but can impact the activity and stability of other transcription factors and proteins. Its ability to modulate different cellular processes highlights its importance in maintaining normal cell function and preventing uncontrolled proliferation.
Pathways
BTG2 is integrated into the tumor suppressor network and influences gene transcription and mRNA degradation pathways. It is connected to the p53 pathway where it functions downstream of p53 a protein that responds to stress signals and maintains genomic stability. BTG2's relationship with the p53 pathway also aligns it with proteins such as MDM2 which helps regulate p53 turnover. This pathway connection showcases BTG2's role in mediating DNA damage responses and maintaining cellular integrity.
BTG2's tumor-suppressive functions associate it particularly with cancer. Abnormal expression or mutations in the BTG2 gene can contribute to the progression of breast and prostate cancers. The loss of BTG2 function leads to unregulated cell proliferation aiding cancer development. Furthermore BTG2's connection to the p53 protein and the latter's involvement in multiple types of cancers establishes a critical link in tumor suppression mechanisms highlighting potential therapeutic targets where BTG2 might play a role.