Abcam, ab85104, Anti-Ghrelin Receptor/GHS-R antibody

Size: 100µg
Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 13 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Rat, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.02% Sodium azideConstituents: 2% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Ghrelin Receptor also known as GHS-R or GHSR is a G protein-coupled receptor responsible for binding ghrelin the hunger hormone which is a ligand composed of ghrelin peptides. The receptor weighing approximately 44 kDa exhibits a chemical structure typical for G-protein-coupled receptors which enables signal transduction across cell membranes. The receptor is expressed extensively in the hypothalamus pituitary gland and other peripheral tissues including heart and adipose tissue indicating its widespread role in energy homeostasis.
Biological function summary
This target modulates several physiological processes. It notably has a significant influence on appetite regulation and energy balance reflecting its function as part of the larger neuroendocrine system. The Ghrelin Receptor does not form a larger protein complex but interacts directly with ghrelin analogues to mediate its effects. This interaction plays a critical role in stimulating growth hormone release influencing metabolic processes.
Pathways
The Ghrelin Receptor is integral to the growth hormone secretagogue pathway where it interacts closely with the growth hormone-releasing hormone receptor (GHRHR). This pathway exemplifies the receptor’s role in energy metabolism and regulation of body composition. In addition to this the receptor is involved in neuroendocrine signaling pathways impacting appetite and feeding behaviors by signaling to orexigenic neurons in the arcuate nucleus of the hypothalamus.
Research indicates that dysregulation of Ghrelin Receptor activity is linked to obesity and metabolic syndromes. Alterations in ghrelin signaling can lead to abnormal energy balance and fat storage. Moreover the receptor is associated with conditions like Prader-Willi Syndrome where ghrelin levels commonly increase exacerbating feeding behaviors. The Ghrelin Receptor's relationship with the growth hormone and its dynamic interaction with GHRHR also highlight its broader relevance in metabolic and growth-related disorders.