Abcam, ab85557, Anti-RTEL1 antibody

Size: 50µg
Rabbit Polyclonal RTEL1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human RTEL1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human RTEL1. The exact immunogen used to generate this antibody is proprietary information.Q9NZ71

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-Preservative: 0.01% Sodium azideConstituents: PBS, 50% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
RTEL1 also known as Regulator of Telomere Elongation Helicase 1 is a helicase protein involved in DNA metabolism. It has a molecular mass of approximately 143 kDa. RTEL1 expresses mainly in the nucleus with high expression in tissues like the testes liver and heart. Mechanistically RTEL1 functions by unwinding DNA during replication and repair processes. This activity helps maintain the integrity of telomeres and prevents telomere dysfunction.
Biological function summary
This protein plays a role in maintaining genome stability and integrity. RTEL1 functions as part of the shelterin complex which protects telomeres from being recognized as DNA damage sites. It interacts with other proteins like TRF2 and POT1 to ensure proper telomere length regulation. By dismantling DNA secondary structures RTEL1 allows for efficient DNA replication and prevents replication stress.
Pathways
Researchers have linked RTEL1 to important pathways involving DNA repair and replication. RTEL1 participates in the homologous recombination and non-homologous end joining pathways which are critical for fixing DNA double-strand breaks. Within these pathways RTEL1 interacts with proteins such as BRCA1 and RAD51 aiding in the resolution of recombination intermediates and maintenance of chromosomal stability.
RTEL1 mutations have associations with various forms of cancer and dyskeratosis congenita. In cancer RTEL1 dysfunction leads to genomic instability contributing to tumorigenesis. In dyskeratosis congenita telomere shortening due to RTEL1 defects results in premature aging and bone marrow failure. The protein associates with TERT in these conditions highlighting its role in telomere length regulation critical for cellular aging and proliferation.