Abcam, ab85570, Anti-alpha 2a Adrenergic Receptor antibody

Size: 100µg
Rabbit Polyclonal alpha 2a Adrenergic Receptor antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 14 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.,
Specificity:From September 2024, QC testing of replenishment batches of this polyclonal changed. All tested and expected application and reactive species combinations are still covered by our Abcam product promise. However, we no longer test all applications. For more information on a specific batch, please contact our Scientific Support who will be happy to help.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The alpha-2a adrenergic receptor also known as alpha-2A adrenoceptor plays an important role in the modulation of neurotransmission. This G-protein coupled receptor with an approximate mass of 50 kDa primarily binds to norepinephrine and epinephrine acting to inhibit adenylate cyclase activity. These receptors are expressed widely in the central nervous system especially in the locus coeruleus and also in peripheral tissues like vascular smooth muscle cells. Through their function alpha-2a receptors regulate several physiological processes including blood pressure and insulin release.
Biological function summary
Alpha-2a adrenergic receptors help modulate neurotransmitter release at presynaptic sites. They are known to form part of a signaling complex involving G proteins. This interaction reduces intracellular cAMP levels which in turn decreases neural excitability and releases neurotransmitters such as norepinephrine. The regulation of neurotransmitter release helps maintain homeostasis in stress response and other physiological states.
Pathways
Alpha-2a adrenergic receptors play significant roles in the adrenergic signaling pathway. This pathway influences various physiological responses as part of the larger catecholamine pathway. Interactions with proteins such as G-protein alpha-i inhibit adenylyl cyclase showcasing how the receptor helps modulate the sympathetic nervous system. Additionally it affects related receptors like the alpha-1 adrenergic receptor which have roles in opposing physiological functions.
Alpha-2a adrenergic receptors have been implicated in hypertension and attention-deficit hyperactivity disorder (ADHD). Their role in vascular smooth muscle cells affects blood pressure regulation linking them to hypertension. In the context of ADHD they interact with proteins involved in executive function and attention playing a part in the disorder's neurochemical basis. Their dysfunction can lead to disrupted signaling pathways contributing to these health issues.