Abcam, ab85853, Anti-ARHGAP29 antibody

Size: 100µg
Rabbit Polyclonal ARHGAP29 antibody. Suitable for WB, IP and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human ARHGAP29 aa 1200 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ARHGAP29 aa 1200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q52LW3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Purification notes-ab85853 was affinity purified using an epitope specific to ARHGAP29 immobilized on solid support., Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ARHGAP29 also known as Rho GTPase Activating Protein 29 is a protein involved in regulating the actin cytoskeleton through its action on Rho family GTPases. This protein has a molecular mass of approximately 145 kDa. It is expressed in various tissues including the heart and the brain. ARHGAP29 acts by stimulating GTPase activity resulting in the inactivation of Rho GTPases which are important for cell morphology migration and adhesion processes.
Biological function summary
ARHGAP29 plays roles in modulating cellular structures and motility by regulating Rho GTPase activity. It functions as a GTPase-activating protein that converts active GTP-bound RhoA Rac1 and Cdc42 to their inactive GDP-bound states. ARHGAP29 is not part of any known major protein complex but interacts with signal transduction molecules to exert its effects on the cytoskeleton.
Pathways
ARHGAP29 is an important regulator within the Rho GTPase signaling pathway influencing actin dynamics that affect cell movement and shape. This protein interacts with and modulates RhoA activity which is involved in the MAPK signaling pathway linking it to broader cellular functions such as growth and differentiation. ARHGAP29 has a relationship with other GTPase-activating proteins collectively contributing to the regulation of the Rho signaling pathway.
ARHGAP29 has been associated with particular conditions like nonsyndromic cleft lip with or without cleft palate and vascular diseases. Mutations or dysregulation of ARHGAP29 can impact cytoskeletal organization influencing tissue morphogenesis and vascular integrity. It connects to other proteins like RhoA whose abnormal regulation often results in similar developmental and vascular disorders.