Abcam, ab85967, Anti-PDLIM5/ENH antibody

Size: 100µL
Rabbit Polyclonal PDLIM5/ENH antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human PDLIM5 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human PDLIM5 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q96HC4

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
PDLIM5/ENH also known as Enhancer of Lim Domain Protein 5 is a cytoskeletal protein with a molecular mass of approximately 62 kDa. This protein is primarily expressed in heart and skeletal muscle tissues. PDLIM5/ENH binds to actin filaments and is involved in organizing the cytoskeleton. It acts as an adapter or scaffold protein linking other proteins to the cytoskeleton and helping in maintaining structural integrity and function in muscle cells.
Biological function summary
PDLIM5/ENH plays a significant role in cardiac muscle development and function. It is also a part of the protein complex that interacts with other cytoskeletal proteins to stabilize actin filament structures. This interaction is important for muscle contraction and cellular signaling. PDLIM5/ENH is also involved in transducing mechanical signals into biochemical signals which affect cell differentiation and growth.
Pathways
PDLIM5/ENH integrates into important signaling pathways like the MAPK and Wnt pathways. In the MAPK pathway PDLIM5/ENH interacts with proteins involving cell growth and differentiation such as ERK. Through the Wnt pathway it plays a role in tissue development and regeneration by working alongside proteins like beta-catenin. These pathways highlight its contribution to essential cellular processes that affect muscle and cardiac function.
PDLIM5/ENH is associated with cardiac hypertrophy and dilated cardiomyopathy. Alterations in its function can impact cardiac muscle structure leading to pathological changes. Additionally its interaction with proteins like desmin in muscle tissues links it to muscle disorder pathologies. Understanding PDLIM5/ENH's role in these diseases may provide insights into therapeutic targets for cardiac and muscle-related disorders.