Abcam, ab86349, Anti-RAB antibody

Size: 100µL
Rabbit Polyclonal RAB antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human AGFG1 aa 500 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human AGFG1 aa 500 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P52594

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The RAB proteins also known as RAS-related proteins are small GTPases with a molecular weight of approximately 20–25 kDa. They belong to the Ras superfamily which are key regulators of intracellular trafficking. RAB proteins primarily localize to specific intracellular membranes where they direct vesicle movement docking and fusion. Different RAB proteins express in distinct tissues reflecting their specific roles in cell function. For example certain RAB proteins predominantly express in the brain while others are found in muscle or epithelial tissues.
Biological function summary
Small GTPases like RAB proteins operate as molecular switches in the cell. They participate in processes such as endocytosis exocytosis and other vesicle transport mechanisms. RAB proteins often work in conjunction with other members of the GTPase family and can assemble into regulatory complexes on vesicle membranes. These complexes control the specificity and timing of vesicle trafficking events ensuring precise delivery of cellular cargo.
Pathways
Small GTPases such as RAB proteins integrate into several key cellular signaling and trafficking pathways. They are vital components of the vesicular transport pathways including the endocytic and secretory pathways. RAB proteins communicate with effector proteins like the SNAREs to facilitate vesicle fusion and regulate membrane dynamics. Additionally they interact with components of the cytoskeleton to ensure vesicle movement within cells influencing both signaling and homeostatic pathways.
Aberrations in RAB proteins often link to neurological disorders and cancer. Mutations or dysregulation of specific RAB proteins can disrupt vesicle transport and lead to pathologies such as Charcot-Marie-Tooth disease or melanoma. In cancer changes in RAB function may alter signaling pathways that control cell proliferation and metastasis. Moreover RAB proteins can have interactions with oncogenes or neuroprotective proteins influencing disease progression and offering potential targets for therapeutic interventions.