Abcam, ab88053, Anti-Choline kinase alpha antibody

Size: 100µg
Rabbit Polyclonal Choline kinase alpha antibody. Suitable for WB, ICC/IF and reacts with Mouse, Human, Rat samples. Cited in 16 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Rat, Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4Preservative: 0.02% Sodium azideConstituents: PBS, 1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Choline kinase alpha also known as CKα or CHKA is an enzyme responsible for catalyzing the first step in the synthesis of phosphatidylcholine converting choline into phosphocholine. This process is important for membrane biosynthesis and cell signaling. Choline kinase alpha has a molecular mass of approximately 45 kDa. It is expressed in various tissues with high levels in liver brain and muscle reflecting its role in both metabolic and proliferative processes. The functional activity of CKα is influenced by its interaction with lipid environments and other cellular factors.
Biological function summary
Choline kinase alpha plays a significant role in cell proliferation and survival due to its involvement in phospholipid metabolism. The enzyme is not known to be part of any large protein complexes but it does interact with a variety of cellular components that regulate its activity. It affects cellular processes by controlling the rate of phosphatidylcholine synthesis therefore impacting membrane dynamics and signal transduction. Changes in CKα activity can result in altered cell growth and function.
Pathways
Choline kinase alpha is an essential part of the Kennedy pathway or the CDP-choline pathway which is a major pathway for phosphatidylcholine biosynthesis. Within this pathway CKα's activity is essential for progressing from choline uptake to the formation of phosphatidylcholine. Other key proteins related through this pathway include CTP:phosphocholine cytidylyltransferase (CCT) and cholinephosphotransferase. The enzyme's function integrates metabolic and signaling pathways connecting lipid metabolism with cellular responses to external stimuli.
Choline kinase alpha aberrations have been linked to cancer and neurodegenerative conditions. Overexpression of CKα is frequently observed in several types of cancer highlighting its role in tumor growth and metastasis. In cancer CKα interacts with oncogenic proteins that further drive malignancy. In neurodegenerative diseases altered choline metabolism may induce neuronal damage but the exact role of CKα in such conditions needs further investigation. Targeting CKα or its pathways could provide therapeutic potential for these disorders.