Abcam, ab88250, Anti-IgA2 antibody

Size: 50µg
Mouse Polyclonal IGHA2 antibody. Carrier free. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human IGHA2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:ICC/IF, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IGHA2.P01877

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
IgA2 also known as Immunoglobulin A2 is an antibody isotype mainly found in mucosal areas. It has a molecular mass of approximately 160 kDa. IgA2 is primarily expressed in the mucosal membranes lining the gut respiratory tract and urogenital tract playing an important role in the immune defense of these surfaces. It differs from IgA1 in the structure of the hinge region which is shorter and less likely to be cleaved by bacterial proteases providing enhanced protection at these sites.
Biological function summary
IgA2 serves as an essential component of the mucosal immune system. It forms complexes with antigenic substances to neutralize pathogens and prevent their adherence to epithelial cells. The dimeric form of IgA2 combined with the secretory component allows it to be effectively transported across mucosal barriers into secretions where it functions without activating complement pathways therefore reducing inflammation. The secretory IgA2 forms a physical barrier on mucosal surfaces trapping microbes and toxins.
Pathways
IgA2 functions within the mucosal immune response pathways and plays an important interaction role with components of the adaptive immune response. It associates with the polymeric immunoglobulin receptor (pIgR) facilitating its transcytosis across epithelial cells into secretions. IgA2 also operates within the immunological network alongside J chain proteins instrumental in forming its dimeric structure important for appropriate secretion and function in mucosal immunity.
IgA2 is connected to immunological conditions like IgA nephropathy and selective IgA deficiency. IgA nephropathy involves deposits of IgA in the kidneys which can lead to inflammatory kidney damage. In selective IgA deficiency individuals may have increased susceptibility to infections at mucosal surfaces due to decreased IgA levels wherein IgA2's role is significant. The interaction of IgA2 with other immunoglobulins becomes a factor in assessing these diseases especially with proteins that influence the immune response's regulation.