Abcam, ab88632, Anti-CCRL2 antibody

Size: 50µg
Mouse Polyclonal CCRL2 antibody. Carrier free. Suitable for Flow Cyt, WB and reacts with Human, Mouse samples. Cited in 6 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CCRL2.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Mouse, Human,
Applications:Flow Cyt, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CCRL2.O00421

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CCRL2 protein also known as CC chemokine receptor-like 2 belongs to the seven-transmembrane domain receptor family. This is a smaller GPCR with an approximate mass of 39 kDa. It does not bind ligands like traditional chemokine receptors but acts more like a decoy. Scientists have found its expression primarily on immune cells including monocytes and macrophages as well as on some endothelial and epithelial cells. The expression can vary depending on the activation state of the cells or tissue type.
Biological function summary
CCRL2 influences immune cell homeostasis and response. It does not function in the same way as classical ligand-binding chemokine receptors but serves as a scavenger or "silent" receptor. This characteristic allows it to sequester ligand availability shaping the local chemokine gradient. Researchers see its activity as closely linked to the regulation of immune responses and inflammation although they haven't fully clarified its role in immune signaling complexes.
Pathways
Scientists see CCRL2 as integral to inflammatory responses and chemotactic pathways. It maintains connections to the CXCR3 and CCR5 pathways systems essential for directing immune cell migration. These interactions help moderate the immune system's response intensity. Investigators have found that CCRL2 influences related proteins such as chemerin contributing to chemokine signaling network modulation.
Researchers associate CCRL2 with inflammatory conditions and cancer. Its atypical receptor function affects the immune landscape in the tumor microenvironment suggesting a role in regulating immune evasion by tumors. Additionally CCRL2 interacts with chemerin in inflammatory diseases impacting conditions like rheumatoid arthritis by potentially controlling inflammatory cell recruitment. This makes CCRL2 an interesting target for therapies aimed at modulating immune system activities in these diseases.