Abcam, ab88686, Anti-ORC6L antibody

Size: 50µg
Mouse Polyclonal ORC6L antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ORC6.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human ORC6.Q9Y5N6

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ORC6L also known as Origin Recognition Complex Subunit 6 is a protein that plays a mechanical role in the initiation of DNA replication. It weighs approximately 30 kDa and localizes in the nucleoplasm of cells. ORC6L is expressed in various tissues with higher expression observed in testis pancreas and thymus. It is an important component ensuring the proper functioning and regulation of DNA replication origins.
Biological function summary
DNA replication relies on ORC6L as part of the origin recognition complex (ORC) a multi-protein assembly essential for marking the origins of replication. The ORC complex of which ORC6L is a vital member initiates the assembly of pre-replicative complexes important for cell cycle progression. By binding to specific DNA sites ORC6L helps recruit other initiation factors ensuring that DNA replication occurs only once per cell cycle maintaining genomic stability.
Pathways
Different phases of the cell cycle require ORC6L's role in the DNA replication pathway. This protein's function connects with other components of the ORC such as ORC1 ORC2 and ORC3 to control replication initiation. Furthermore ORC6L interacts with proteins such as CDC6 and MCM integrating into the DNA replication licensing pathway which ensures the cell's readiness for DNA synthesis and subsequent divisions.
Mutations or dysregulation of ORC6L have implications for genomic instability and diseases like Meier-Gorlin syndrome. This condition characterized by growth retardation and skeletal anomalies often links to other ORC components including ORC1 and ORC4 illustrating its involvement in developmental abnormalities. Additionally cancer research indicates the possible connection between ORC6L dysfunction and tumorigenesis due to unchecked cell proliferation emphasizing its importance in maintaining a balanced cell division process.