Abcam, ab89274, Anti-UGT2B15 antibody

Size: 50µg
Mouse Polyclonal UGT2B15 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human UGT2B15.
Key facts
Host species:Mouse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human UGT2B15.P54855

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
UGT2B15 also known as UDP-glucuronosyltransferase 2B15 plays an important role in the glucuronidation process. This enzyme belongs to the UDP-glycosyltransferase family and facilitates the attachment of glucuronic acid to small lipophilic molecules making them more water-soluble. UGT2B15 has a mass of approximately 56 kDa and finds its expression mainly in the liver but also in other tissues such as the prostate and testis. This distribution suggests its importance in the metabolism of various endogenous and exogenous compounds.
Biological function summary
Enzymes like UGT2B15 are important in the detoxification of substances. UGT2B15 facilitates the metabolism and clearance of steroid hormones including androgens and nonsteroids such as drugs. It does not operate as part of a larger complex but works individually to modify substrates. This process converts lipophilic drugs and hormones into more excretable forms aiding in homeostasis.
Pathways
UGT2B15 functions within important metabolic pathways such as steroid metabolism and drug detoxification pathways. In these pathways it interacts with other UGT family members such as UGT2B17 to ensure the efficient metabolism of various substrates. Their actions help regulate steroid levels and detoxify therapeutic drugs keeping physiological functions balanced by preventing the accumulation of potentially harmful compounds.
Researchers associate UGT2B15 with conditions like prostate cancer and drug resistance. Altered expression or function of this enzyme may contribute to the development and progression of prostate cancer by affecting androgen metabolism. Additionally UGT2B15 plays a role in drug resistance often seen in therapies involving anti-cancer agents that require metabolic activation for clearance. Its activity connects with related proteins such as UGT2B17 influencing the progression and treatment responses in these conditions.