Abcam, ab90855, Anti-TREK1 antibody

Size: 100µL
Rabbit Polyclonal KCNK2 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
TREK1 also known as K2P2.1 or KCNK2 is a two-pore domain potassium channel involved in the regulation of ion flow across the cell membrane. The molecular mass of TREK1 is approximately 49 kDa. It is widely expressed in the central nervous system including brain regions such as the hippocampus and cerebellum as well as in peripheral tissues like the heart and skeletal muscle. TREK1 allows potassium ions to move in response to changes in voltage temperature and pressure contributing to the maintenance of the cell's resting membrane potential.
Biological function summary
TREK1 influences neuronal excitability and is part of a complex involved in sensing mechanical and temperature changes. It plays a role in neuroprotection by helping neurons adapt to metabolic stress and hypoxia. TREK1 activity can modulate neurotransmitter release and influence synaptic transmission affecting processes like pain perception and mood regulation. Its function as a background conductance channel ensures the stabilization of the membrane potential in excitable cells.
Pathways
Studies identify TREK1 in the regulation of the serotoninergic pathway and the pain modulation mechanism. It influences serotonin release affecting mood and anxiety levels. TREK1 function also impacts the action of related proteins like TASK and TRAAK which are members of the same two-pore domain potassium channel family serving in overlapping physiological processes including modulation of neuronal activity and response to anesthetics.
Research associates TREK1 dysfunction with depression and epilepsy. Reduced activity of TREK1 links to depressive states as it influences serotonin system modulation potentially interacting with proteins such as G-proteins implicated in mood disorders. TREK1's role in controlling neuronal excitability connects it to epilepsy where malfunction can lead to hyper-excitability and seizure episodes. Understanding TREK1's involvement in these pathways opens potential therapeutic strategies for these conditions.