Abcam, ab91556, Anti-NCBP2 antibody

Size: 100µg
Rabbit Polyclonal NCBP2 antibody. Suitable for IHC-P, IP and reacts with Human samples. Cited in 4 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCBP2 also known as Nuclear Cap-Binding Protein Subunit 2 is an essential component of the mRNA cap-binding complex. This protein weighs approximately 97 kDa and is expressed widely in various tissues. NCBP2 plays a mechanical role in binding the cap structure of nascent RNA. It stabilizes the capped RNA which is important for mRNA regulation. By helping to mediate initial mRNA processing NCBP2 assists in ensuring proper RNA splicing and stability.
Biological function summary
The cap-binding function of NCBP2 influences gene expression by facilitating mRNA export and translation. NCBP2 is a part of the nuclear cap-binding complex or CBC which forms a heterodimer with NCBP1. This complex interacts with numerous other proteins to impact mRNA lifecycle processes. Its role in connecting splicing factors highlights its contribution to RNA metabolism and cellular proliferation.
Pathways
The interaction of NCBP2 significantly impacts the mRNA surveillance and nonsense-mediated decay pathways. These pathways ensure that defective mRNAs do not accumulate inside cells. Here NCBP2 interacts closely with other associated proteins like UPF1 which aids in identifying mRNAs targets for degradation. The protein also links with proteins SR proteins coordinating efficient splicing and proper mRNA processing.
Several studies link NCBP2 disruptions to certain inflammatory and neurodegenerative disorders. Changes in its expression or mutations may influence neurologic diseases like familial dysautonomia a condition involving the nervous system. In this context NCBP2 interacts with IKAP a protein important in neuronal survival. Understanding these associations may help in developing therapeutic strategies that target NCBP2's roles within cellular processes.