Abcam, ab9193, Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) antibody

Size: 100µg / 500µg
Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) antibody (ab9193) is a horse polyclonal antibody detecting Hepatitis B Virus Surface Antigen (Ad/Ay) in ELISA . Suitable for Hepatitis B virus . - Over 30 publications - Trusted since 2002
Key facts
Host species:Horse,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Hepatitis B virus,
Applications:I-ELISA, ELISASee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Specificity:This antibody is specific for Hepatitis B surface antigen

Product details:
What is this antibody validated in?
Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) antibody (ab9193) is a horse polyclonal antibody and is validated for use in ELISA in Hepatitis B virus samples.
Trusted by the scientific community
Anti-Hepatitis B Virus Surface Antigen (Ad/Ay) (ab9193) was first used in a scientific publication in 2002 and has been cited over 30 times in peer-reviewed journals.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification, Purification notes-This antibody was immunoaffinity purified from non-recombinant hepatitis antigens., Storage buffer-pH: 7.2 Preservative: 0.09% Sodium azide Constituents: 99.9% PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Hepatitis B Virus Surface Antigen (HBsAg) also known as Hepatitis B surface antigen AD/AY serves as a significant marker for the Hepatitis B virus (HBV). This glycoprotein displays a molecular mass of approximately 24 kDa and consists of small medium and large protein forms. HBsAg is typically expressed in the infected liver cells and secreted into the bloodstream. This expression allows its use as a diagnostic marker for HBV infection through assays like HBsAg ELISA which detects the presence of the virus.
Biological function summary
The surface antigen plays an important role in the virus's attachment and entry into hepatocytes. HBsAg forms part of the viral envelope structure which facilitates the virus's ability to infect host cells. The presence of HBsAg is linked to an individual’s immune response specifically the production of hepatitis antibodies. Its interaction with the host’s immune system and antibodies like hep B antibodies are essential for understanding both viral pathogenesis and immunity to HBV infections.
Pathways
The Hepatitis B virus surface antigen plays critical parts in the infectious cycle and immune response pathways. One important pathway includes the endocytosis pathway where HBsAg is involved in the virus's entry into liver cells. The surface antigen also interacts with the human immune system influencing the expression of Hepatitis B antibodies. Connected proteins include those involved in the immune signaling where alterations affect the body's ability to mount an effective response against HBV.
The Hepatitis B Virus Surface Antigen is directly associated with Hepatitis B infection and its progression. Chronic HBV infection may lead to liver-related diseases such as cirrhosis and hepatocellular carcinoma. HBsAg presence serves as an indicator for diagnosing these liver diseases. The antigen's interaction with other viral proteins such as the core antigen and E antigen are important in the disease's progression and overall clinical outcomes.