Abcam, ab92540, Anti-SAA4 antibody [EPR2926]

Size: 100µL / 1mL
Rabbit Recombinant Monoclonal SAA4 antibody. Suitable for WB, Flow Cyt (Intra), IHC-P and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Monoclonal,
Clone number:EPR2926,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, Flow Cyt (Intra), WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Product details:
Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
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contact us
for more information.
Patented technology
Our RabMAb
technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to
RabMAb® patents
What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on
recombinant antibodies

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.2 - 7.4Preservative: 0.05% Sodium azideConstituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Serum Amyloid A4 (SAA4) also known as C-SAA is a minor apolipoprotein associated with high-density lipoprotein (HDL) in plasma. SAA4 is a protein of approximately 14 kDa in mass. It is mainly expressed in the liver and secreted into the bloodstream. The protein exists in a tetrameric form and is part of the SAA family which has four known human isoforms: SAA1 SAA2 SAA3 and SAA4.
Biological function summary
SAA4 plays a role in lipid metabolism and transport. Unlike SAA1 and SAA2 SAA4 is not significantly upregulated during acute-phase inflammatory responses. SAA4 works by stabilizing HDL particles and influencing cholesterol transport. It does not participate actively in the inflammatory response which distinguishes it from other SAA proteins. As part of the lipoprotein complex it contributes to maintaining lipid homeostasis.
Pathways
SAA4 participates in pathways associated with lipid transport and metabolism. It is involved in the reverse cholesterol transport pathway an essential system to transfer cholesterol from tissues back to the liver. SAA4 shares functional characteristics with apolipoprotein A1 (ApoA1) another key protein in HDL metabolism. Both proteins contribute to cholesterol efflux and transport although SAA4 has more structural than regulatory roles.
SAA4 has connections to cardiovascular disease and amyloidosis. Researchers have identified altered levels of SAA4 in patients with cardiovascular conditions suggesting a link to atherosclerosis. In amyloidosis although SAA4 is not a primary amyloid component its amyloidogenic potential raises interest in studying its involvement. A clear association exists between SAA4 and ApoA1 in these disorders given their shared role in HDL structure and metabolism.