Abcam, ab92606, Anti-HB9/HLXB9/MNX1 antibody

Size: 100µg
Rabbit Polyclonal Motor neuron and pancreas homeobox protein 1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 11 publications.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.05% Sodium azideConstituents: PBS, 0.05% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HB9 also known as HLXB9 and MNX1 plays a mechanical role as a transcription factor in spinal motor neurons and pancreatic islets. With a molecular mass of approximately 40 kDa HB9 expression occurs mainly in the developing central nervous system and pancreas. This protein regulates the expression of genes involved in motor neuron identity and pancreatic beta-cell development. Experts often use HB9 as a marker in developmental biology due to its specific expression pattern in the spinal cord and pancreas.
Biological function summary
HB9 regulates the development and maintenance of motor neurons and pancreatic beta-cells being essential for normal function. It does not form part of a larger protein complex but interacts with various DNA sequences to influence gene transcription. Its activity plays a critical role in ensuring the proper differentiation of cell types during embryonic development.
Pathways
HB9 is integral to both the motor neuron differentiation pathway and pancreas morphogenesis. The Sonic Hedgehog (SHH) signaling pathway interacts with HB9 during the specification of spinal motor neurons. In the pancreas HB9 regulates pathways involving insulin-producing beta-cell formation alongside other transcription factors like PDX1 which closely interact with HB9 functions in pancreas development.
HB9 mutations or misregulation connect with conditions such as Currarino syndrome and type 2 diabetes. Currarino syndrome results from mutations affecting HLXB9 function leading to malformations and neuropathologies. In diabetes impaired HB9 function can disturb beta-cell formation or function exacerbating glucose metabolism disorders. HB9's link with PDX1 further highlights its relevance in diabetes as both proteins play roles in pancreatic development and function.