Abcam, ab9286, Anti-Epithelial Keratin Type I antibody [AE1]

Size: 125µg
Mouse Monoclonal Epithelial Keratin Type I antibody. Suitable for IHC-P, IHC-Fr, WB and reacts with Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle samples. Cited in 14 publications. Immunogen corresponding to Native Full Length Protein corresponding to Human KRT1.
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:AE1,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Mouse, Rat, Rabbit, Chicken, Cow, Monkey, Turtle,
Applications:IHC-Fr, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Native Full Length Protein corresponding to Human KRT1.P04264

Properties and Storage Information:
Form-Liquid, Purity-Tissue culture supernatant, Storage buffer-pH: 7.3Preservative: 0.1% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Epithelial Keratin Type I also known as cytokeratin or CK is a family of cytoskeletal proteins found in the epithelial cells. These proteins are usually around 40-67 kDa in mass. Epithelial Keratin Type I is essential for structural integrity and mechanical strength of epithelial cells. It mainly expresses in epithelial tissues including skin hair and nails and serves a critical role in forming the intermediate filament network.
Biological function summary
These keratins provide stability to cell architecture and protect cells from mechanical and non-mechanical stresses. Epithelial Keratin Type I proteins form heterodimers by pairing with Type II keratins creating filaments that are part of a larger complex. These structures are vital for maintaining the correct function and shape of cells in tissues and they also play a role in cell signaling processes.
Pathways
Epithelial Keratin Type I participates in key pathways like the cytoskeletal signaling and epidermal growth factor (EGF) signaling. These pathways involve interactions with proteins such as keratin 8 and keratin 18. These keratins facilitate communication within cells and help mediate responses to external signals therefore influencing cell proliferation differentiation and apoptosis.
Mutations or dysfunctions in Epithelial Keratin Type I have links to skin diseases such as epidermolysis bullosa simplex and psoriasis. These conditions can result from altered interactions with other keratins such as keratin 5 and keratin 14 disrupting the normal function and structure of epithelial tissues. Such disorders highlight the importance of Epithelial Keratin Type I in maintaining healthy skin and its barrier functions.