Abcam, ab93865, Anti-EYA4 antibody

Size: 100µg
Rabbit Polyclonal EYA4 antibody. Suitable for IP, WB and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human EYA4 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human EYA4 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.O95677

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7 - 8Preservative: 0.09% Sodium azideConstituents: Tris citrate/phosphate, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
EYA4 also known as Eyes Absent 4 is a protein involved in several important cellular processes. It has an approximate molecular mass of 64 kDa. This protein acts as a phosphatase removing phosphate groups from specific proteins. EYA4 is expressed in various tissues including the heart brain and kidneys. Its presence in these diverse tissues indicates its importance in multiple cellular functions.
Biological function summary
EYA4 contributes to the DNA damage repair process and is important for normal cellular development and function. The protein exists as part of a transcriptional complex often interacting with other proteins to regulate gene expression. This interaction suggests a role in cellular differentiation and proliferation supporting healthy developmental processes and maintaining cell health over time.
Pathways
EYA4 plays an integral role in the Notch signaling and DNA repair pathways. In the Notch signaling pathway it associates with the transcription co-activator protein YAP to influence cell fate decisions. This involvement highlights its importance in cellular architecture maintenance. Its function in the DNA repair pathway further links it with the ATM protein coordinating effective responses to genomic stress and preserving genomic integrity.
Alterations in EYA4 expression or function can contribute to sensorineural hearing loss and certain types of cancer including breast cancer. Defective EYA4 interactions with the protein SIX1 have been linked to hearing impairments. In cancer biology aberrant EYA4 function may disrupt its DNA repair capability facilitating genomic instability and tumor progression indicating a critical role in maintaining cellular homeostasis and preventing disease.