Abcam, ab9388, Anti-Interferon alpha 2b antibody [4E10]

Size: 100µL
Anti-Interferon alpha 2b antibody [4E10] (ab9388) is a mouse monoclonal antibody detecting Interferon alpha 2b in Western Blot . Suitable for Human . - Trusted since 2002
Key facts
Host species:Mouse,
Clonality:Monoclonal,
Clone number:4E10,
Isotype:IgG1,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human IFNA2.P01563

Product details:
Anti-Interferon alpha 2b antibody [4E10] (ab9388) is a mouse monoclonal antibody and is validated for use in WB.
Abcam's high quality validation processes ensure Anti-Interferon alpha 2b antibody [4E10] (ab9388) has high sensitivity and specificity.
Anti-Interferon alpha 2b antibody [4E10] (ab9388) specifically detects Interferon alpha 2b (UniProt ID: P01563; Molecular weight: 22kDa) and is sold in 100 µL selling sizes.
Antibody clone 4E10 is also available pre-conjugated to a variety of labels for your convenience - HRP (
ab5258
Interferon alpha 2b helps the immune system fight viral infections and certain cancers by enhancing the body's natural defense mechanisms. Interferon alpha 2b has been implicated in hepatitus B and C, lymphoma and malignant melanoma

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.2 - 7.4Preservative: 0.1% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Interferon alpha 2b also known as IFN-alpha 2b or alpha 2b interferon is a type I interferon protein with an average molecular weight of approximately 19000 Daltons. The protein plays a role in the immune response by exhibiting antiviral antiproliferative and immunomodulatory activities. It is expressed mainly in leukocytes such as lymphocytes macrophages and dendritic cells. Researchers can buy interferon online for laboratory uses or create custom alpha 2b interferon for specific research needs.
Biological function summary
Interferon alpha 2b stimulates the immune system to attack pathogens by enhancing antigen presentation and activating natural killer cells and macrophages. It does not function as part of a complex and it acts independently to initiate an antiviral state in cells and increase the host's defense mechanisms. Its role in regulating cell growth and differentiation adds to its importance in maintaining immune homeostasis.
Pathways
Interferon alpha 2b is involved in the JAK-STAT signaling pathway which induces transcription of interferon-stimulated genes that orchestrate an immune response. Additionally it plays a role in the interferon signaling pathway which contributes to innate immunity. Proteins related to it through these pathways include STAT1 and STAT2 which collaborate with IFN alpha-b protein to transmit signals from extracellular stimuli to the nucleus resulting in gene activation.
Interferon alpha 2b is associated with chronic hepatitis C and certain types of cancer including melanoma. It engages with viral proteins in hepatitis C aiming to clear the virus and reduce liver damage. In cancer the antiproliferative properties of interferon alpha 2b help to inhibit tumor cell growth. In these contexts it connects with proteins such as PKR which helps mediate antiviral and anti-tumor responses.