Abcam, ab95065, Anti-FRYL antibody

Size: 100µL
Rabbit Polyclonal FRYL antibody. Suitable for WB, IP and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human FRYL aa 2600-2650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IP, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human FRYL aa 2600-2650. The exact immunogen used to generate this antibody is proprietary information.O94915

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The FRYL protein also known as FYVE RhoGEF and PH domain-containing protein has a molecular mass of approximately 400 kDa. It is a member of the large family of proteins that contain FYVE domains which typically are involved in binding phosphatidylinositol 3-phosphate lipids. This protein expresses widely across tissues with notable levels found in the brain pancreas and kidney. FRYL's structure includes unique domains that facilitate its various functions within the cell.
Biological function summary
The FRYL protein engages in cellular functions such as cytoskeletal organization and membrane trafficking. It often participates in multiprotein complexes involving other proteins that regulate intracellular processes like cell movement and growth. Due to its domain composition FRYL interacts with lipids present in cellular membranes influencing the spatial arrangement of these membranes.
Pathways
The FRYL protein integrates into key cellular signaling pathways including the PI3K/AKT signaling pathway. This pathway plays a significant role in regulating cell survival and proliferation. FRYL interacts with other proteins such as Rho family GTPases which are essential for cytoskeletal dynamics and cellular architecture. Through these interactions FRYL indirectly connects to various signaling events within cells.
FRYL links to conditions such as cancer and neurological disorders. Abnormal expression or mutations of FRYL can lead to disrupted cellular processes that contribute to oncogenesis and neurodegenerative conditions. Connections with the protein AKT known for its involvement in cancer progression highlight FRYL's potential role in the development of these diseases. Understanding FRYL's functions offers insights into therapeutic targets for diseases affected by its dysregulation.