Abcam, ab95963, Anti-NSFL1C antibody

Size: 50µL
Rabbit Polyclonal NSFL1C antibody. Suitable for WB, IHC-P, IP and reacts with Human, Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human NSFL1C aa 1-300.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human NSFL1C aa 1-300. The exact immunogen used to generate this antibody is proprietary information.Q9UNZ2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NSFL1C also known as p97 cofactor p47 is a protein involved in cellular functions related to NSF ATPases. The protein has a mass of approximately 47 kDa. NSFL1C is expressed in various tissues throughout the body where it plays an active role in modulating interactions between cellular structures. This protein mainly functions by regulating membrane fusion events and protein degradation working closely with other components to maintain cellular integrity.
Biological function summary
NSFL1C acts as an important modulator in cellular homeostasis often participating in complexes with other proteins like p97/VCP a well-known AAA ATPase. This partnership allows NSFL1C to influence diverse cellular activities including endoplasmic-reticulum-associated protein degradation (ERAD) ensuring the removal of misfolded proteins. Therefore NSFL1C helps maintain protein quality control a critical cellular process that prevents accumulation of dysfunctional proteins.
Pathways
NSFL1C connects closely with the ubiquitin-proteasome pathway and autophagy process. Through its association with p97/VCP NSFL1C facilitates the disassembly and recycling of ubiquitinated proteins highlighting its role in cellular proteostasis. Another key pathway involves its cooperation with complexes involved in membrane trafficking linking NSFL1C to cellular transport mechanisms. These associations enable it to coordinate the removal of defective proteins and contribute to regular cellular operations.
NSFL1C alterations contribute to the pathology of neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS) and inclusion body myopathy. Mutations in NSFL1C or its partner protein p97/VCP have been implicated in these conditions leading to impaired clearance of misfolded proteins and disrupted cellular functions. An understanding of NSFL1C's role in these disorders highlights the importance of investigating therapeutic strategies targeting protein quality control mechanisms.