Abcam, ab95969, Anti-CYFIP2 antibody

Size: 50µL
Rabbit Polyclonal CYFIP2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 13 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CYFIP2 aa 300-650.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CYFIP2 aa 300-650. The exact immunogen used to generate this antibody is proprietary information.Q96F07

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The 'CYFIP2' protein also known as the Cytoplasmic FMR1 Interacting Protein 2 plays a critical role in cellular processes. It has a molecular mass of approximately 140 kDa. CYFIP2 is widely expressed in various tissues but its expression is particularly notable in the brain. It acts as a component of a protein complex that regulates the actin cytoskeleton which is essential for maintaining cell structure and function.
Biological function summary
CYFIP2 influences cellular signaling and synaptic growth. It forms part of the WAVE regulatory complex playing a part in actin filament assembly by nucleating actin-related proteins. This biological activity is essential for neurite outgrowth and synaptic plasticity processes important for proper neural function. CYFIP2's interaction with other components of the neuronal cytoskeleton reveals its importance in nervous system development.
Pathways
CYFIP2 integrates into the Rho-GTPase signaling and mTOR pathways. It acts in conjunction with other proteins like Rac1 which activates the WAVE complex leading to actin cytoskeleton remodeling. This coordination is critical for cellular functions such as morphogenesis migration and intracellular transport. Another important interaction involves mTOR signaling as CYFIP2 influences protein synthesis and cell growth through this pathway.
Dysfunction in CYFIP2 links to neurological conditions including intellectual disability and autism spectrum disorders. These disorders arise due to mutations affecting CYFIP2's role in synaptic plasticity and development. CYFIP2's interaction with FMRP (Fragile X Mental Retardation Protein) plays a significant role as both proteins coordinate to manage synaptic signaling and structural stability in neural tissues with anomalies potentially leading to disease manifestations.