Abcam, ab95995, Anti-INPP5B antibody

Size: 50µL
Rabbit Polyclonal INPP5B antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:The exact immunogen used to generate this antibody is proprietary information.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
INPP5B or Type II inositol polyphosphate-5-phosphatase B catalyzes the dephosphorylation of phosphatidylinositol 45-bisphosphate. This enzyme removes the 5-phosphate group from inositol phosphates impacting phosphoinositide signaling pathways. The protein has a mass of approximately 75 kDa and is mainly expressed in the cytosol of cells including kidney and testis tissues. Scientists also observe its expression in other tissues related to phosphoinositide metabolism and signaling.
Biological function summary
INPP5B regulates cellular processes by modulating signaling events. This protein controls calcium signal transduction impacting cell proliferation and motility. INPP5B is part of the inositol phosphate signaling complex which plays a role in maintaining cellular phosphoinositide balance. Its enzymatic activity influences diverse cellular functions important for normal developmental processes and homeostasis.
Pathways
INPP5B participates in the phosphatidylinositol signaling system and calcium signaling pathways. In the phosphatidylinositol pathway INPP5B interacts with other inositol polyphosphate phosphatases like SHIP1 and PTEN working together to regulate phosphoinositide turnover and cellular respond to stimuli. In calcium signaling it closely interacts with proteins controlling intracellular calcium levels thereby influencing diverse cellular responses.
INPP5B links to Lowe syndrome and Dent disease. Mutations affecting INPP5B's enzymatic activity can disrupt normal inositol phosphate metabolism impacting cellular functions and organ development. These diseases also show association with OCRL another inositol phosphatase. OCRL mutations share similar phenotypes with INPP5B dysfunctions causing similar disruptions in kidney and neurological systems highlighting their critical roles in maintaining phosphoinositide homeostasis.