Abcam, ab96159, Anti-PGCP antibody

Size: 50µL
Rabbit Polyclonal PGCP antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CPQ.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CPQ. The exact immunogen used to generate this antibody is proprietary information.Q9Y646

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein PGCP also known as plasma glutamate carboxypeptidase functions mechanically by catalyzing the cleavage of C-terminal glutamate residues from its substrates. PGCP with a molecular mass approximately 55 kDa is highly expressed in the liver and kidney. Researchers have observed its expression in both human and mouse tissues which implies a conserved role across species. PGCP participates in processes that maintain proper levels of free glutamate an important amino acid in metabolic pathways.
Biological function summary
PGCP modulates the balance of circulating peptides by hydrolyzing carboxy-terminal glutamate. It does not operate as part of a larger protein complex but functions independently. By regulating peptides PGCP helps in processes like protein degradation and recycling. It also influences the bioavailability of certain hormones and metabolites thereby affecting metabolic and signal transduction pathways.
Pathways
PGCP actively partakes in the regulation of blood coagulation and metabolism of amino acids. It interacts with proteins like angiotensin II as it processes bioactive peptides involved in blood pressure regulation. Through these actions PGCP affects the renin-angiotensin system which plays a critical role in cardiovascular health. Additionally PGCP associates with amino acid metabolism pathways where its role in glutamate modulation supports cellular energy production and neurotransmitter synthesis.
PGCP's dysregulation connects it to hypertension and metabolic syndrome. Researchers link altered PGCP activity with imbalances in the renin-angiotensin system leading to increased blood pressure. Furthermore its interaction with proteins like bradykinin influences inflammatory responses and researchers hypothesize its involvement in metabolic syndrome due to its role in amino acid processing. Understanding PGCP's contributions aids in exploring therapeutic interventions for these conditions.