Abcam, ab96184, Anti-CTNNAL1 antibody

Size: 50µL
Rabbit Polyclonal CTNNAL1 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 5 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Alpha-catulin aa 250-550.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Alpha-catulin aa 250-550. The exact immunogen used to generate this antibody is proprietary information.Q9UBT7

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CTNNAL1 also referred to as catenin alpha-like 1 is a protein with a mass of approximately 100 kDa. It is expressed in various tissues including the brain and testis. This protein plays a role in cell adhesion and cytoskeletal organization by interacting with other cellular components. CTNNAL1 is involved in serving as a linker molecule that connects the cytoskeleton to the extracellular matrix maintaining the structural integrity of cells.
Biological function summary
CTNNAL1 contributes to cellular processes through its role in cell-cell adhesion and signaling pathways. It does not function alone but rather as part of a multi-protein complex involving proteins such as beta-catenin and alpha-catenin. This complex formation is essential for stabilizing cell junctions and facilitating communication between cells. Through its interactions CTNNAL1 maintains cellular architecture and supports signal transduction essential for tissue development and maintenance.
Pathways
CTNNAL1 participates in the Wnt signaling and adherens junction pathways. In the Wnt signaling pathway CTNNAL1 influences beta-catenin activity a critical protein for signal transduction and gene expression regulation. In the adherens junction pathway CTNNAL1 works closely with alpha-catenin to mediate cell adhesion processes that are important for tissue structure and cellular communication.
CTNNAL1 has associations with cancer and neurodevelopmental disorders. Alterations in CTNNAL1 expression or function can impact cell adhesion and signaling contributing to cancer progression particularly in the context of aberrant Wnt signaling which involves beta-catenin as an important player. Additionally disruptions to the proteins' role in neural tissue can lead to neurodevelopmental issues often linked to irregularities in cellular structure and signaling within the central nervous system.