Abcam, ab9664, Anti-ILP2 antibody

Size: 100µg
Rabbit Polyclonal ILP2 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Synthetic Peptide within Human BIRC8 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human BIRC8 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q96P09

Product details:
Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family including IAP, XIAP/ILP-1/MIHA, and Livin/KIAP that bind to and inhibits specific proteases. A novel member in the IAP protein family was recently identified and designated ILP-2 for IAP-like protein-2 (1). ILP-2 has high homology to ILP-1, but is encoded by a distinct gene that is solely expressed in testis of tested normal human tissues (1). ILP-2, unlike ILP-1, has no inhibitory effect on Fas and TNF induced apoptosis, but potently inhibits apoptosis induced by overexpression of Bax or by coexpression of caspase-9 with Apaf-1. ILP-2 interacts with the processed caspase-9. These results suggest that ILP-2 is a novel IAP family member with restricted specificity for caspase-9.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein ILP2 also known as Inhibitor of Apoptosis Protein 2 plays an important role mechanically by acting as an apoptotic suppressor. ILP2's estimated molecular mass is approximately 32 kDa. Expression mostly occurs in testicular tissues though traces are present in other tissues. ILP2 shares structural and functional similarities with other members of the inhibitor of apoptosis protein (IAP) family which allow it to interact closely with various cellular components.
Biological function summary
The protein functions by preventing cell death providing essential support for cellular survival. ILP2 is part of a complex that includes other IAPs and operates in the regulation of apoptosis. Its action directly inhibits caspases which are enzymes critical for the execution phase of cell apoptosis. This function is significant as it contributes to the balance between cell proliferation and death making ILP2 an important player in cellular homeostasis.
Pathways
The protein acts in critical signaling pathways related to cell survival and apoptosis like the NF-kB signaling pathway. ILP2 works in conjunction with proteins such as XIAP and c-IAP1 which participate in similar pathways contributing to protection against unwanted cell death. This involvement helps maintain normal cellular processes and supports proper functioning of tissues.
The protein ILP2 has been implicated in different malignancies including testicular cancer and some leukemia forms. ILP2 may lead to disease progression by preventing apoptosis which allows cancer cells to survive longer than they should. In these diseases ILP2 often interacts with other apoptosis inhibitors like XIAP and Survivin increasing the complexity of the therapeutic targets associated with cancer treatment.