Abcam, ab96677, Anti-CARHSP1 antibody

Size: 50µL
Rabbit Polyclonal CARHSP1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CARHSP1 aa 1 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human CARHSP1 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.Q9Y2V2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: PBS, 10% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CARHSP1 also known as Calcium-regulated Heat Stable Protein 1 is a 15 kDa protein. It plays a significant role in RNA-binding and stabilization influencing RNA metabolism. This protein is expressed in various human tissues including liver heart and muscle which suggests its importance across different biological processes. CARHSP1 has a strong affinity for specific RNA sequences which contributes to its function in post-transcriptional regulation.
Biological function summary
CARHSP1 influences cellular stress responses through its role in RNA stability. It associates with RNA-protein complexes modulating the expression of stress-responsive genes. This protein becomes particularly active under stress conditions like heat shock facilitating survival and adaptation. Its interaction with other elements of the stress granules points to its integrative role in cellular adaptability mechanisms.
Pathways
CARHSP1 participates prominently in post-transcriptional gene regulation pathways. The protein is actively involved in the stress response pathway where it stabilizes target mRNAs during cellular stress conditions. CARHSP1 interacts with proteins such as TIA1 and G3BP key players in the assembly of stress granules further assisting in the stabilization and regulation of specific mRNA transcripts.
Studies suggest that CARHSP1 has implications in certain cancer types and neurodegenerative diseases. Its overexpression or dysregulation may contribute to oncogenic processes in some cancers possibly due to its role in mRNA stabilization of proliferation-related genes. Additionally alterations in CARHSP1 function might relate to neurodegenerative diseases where aberrant stress response pathways are often observed. It connects with proteins like Hsp70 which are also involved in stress and disease response pathways further underlining its potential impact on these conditions.