Abcam, ab97396, Anti-ACT antibody

Size: 50µL
Rabbit Polyclonal ACT antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FHL5 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human FHL5 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q5TD97

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 10% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
ACT also known as Alpha-1-antichymotrypsin is a serine protease inhibitor primarily involved in inhibiting enzymes like cathepsin G and chymase. It has a molecular mass of approximately 68 kDa. This protein is mainly expressed in hepatocytes but can also be found in other tissues including the lungs and intestines. Its role in the immune response and inflammation is significant given its protease inhibitory function.
Biological function summary
Alpha-1-antichymotrypsin plays a critical role in controlling proteolytic activities to prevent tissue damage during inflammation. As part of a family of serine protease inhibitors it forms complexes with its target enzymes thereby regulating their activity. This regulation is vital for maintaining homeostasis in bodily tissues especially during acute phase responses in the liver.
Pathways
Alpha-1-antichymotrypsin is involved in the acute phase response pathway which is key in modulating inflammation and responding to tissue injury. It also participates in the complement and coagulation cascades. Proteins such as C-reactive protein and other serine protease inhibitors are linked through these pathways working together to manage the body's response to damage and infection.
Abnormalities in Alpha-1-antichymotrypsin function have been linked to chronic obstructive pulmonary disease (COPD) and Alzheimer's disease. Deficiencies or mutations in this protein can exacerbate the protease-antiprotease imbalance in COPD. In Alzheimer's disease ACT is known to associate with amyloid plaques possibly influencing their formation or stability. Other proteins like the amyloid-beta peptide are connected through these diseases highlighting the complex interplay between ACT and pathological processes.