Abcam, ab9835, Anti-SCGF beta antibody

Size: 100µg
Goat Polyclonal SCGF antibody. Suitable for ELISA, WB, sELISA and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLEC11A.
Key facts
Host species:Goat,
Clonality:Polyclonal,
Isotype:Unknown,
Light chain type:unknown,
Carrier free:No,
Reacts with:Human,
Applications:sELISA, ELISA, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human CLEC11A.Q9Y240

Properties and Storage Information:
Form-Lyophilized, Reconstitution-reconstitute with water at 200µL, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.4, Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SCGF beta also known as stem cell growth factor beta or CLEC11A is a cytokine with a mass of approximately 32 kDa. It is expressed in various tissues including bone marrow spleen and liver. SCGF beta plays a role in hematopoiesis influencing the growth and differentiation of stem cells. The protein interacts with surface receptors on target cells leading to intracellular signaling cascades that drive its functions.
Biological function summary
SCGF beta promotes the proliferation and differentiation of hematopoietic progenitor cells. It serves as a mediator in the bone marrow microenvironment supporting the survival and maintenance of stem cells. While it functions independently SCGF beta may interact with other cytokines to optimize the hematopoietic process. Its activity is not known to rely on a larger protein complex.
Pathways
SCGF beta is integral to the hematopoietic and immune response pathways. It contributes significantly to erythropoiesis and granulopoiesis key components of blood cell formation. In these pathways SCGF beta relates closely to proteins like G-CSF and GM-CSF which also stimulate granulocyte and macrophage lineage differentiation. Together these proteins ensure the proper development and function of blood cells and the immune system.
SCGF beta has associations with conditions such as leukemia and bone marrow failure syndromes. Altered expression or malfunction of SCGF beta may contribute to the pathogenesis of these disorders by disrupting normal hematopoietic processes. In leukemia a relationship exists between SCGF beta and proteins like FLT3 where mutations can exacerbate the condition by affecting cell signaling and growth. Understanding SCGF beta's role in these diseases may provide insight into better therapeutic strategies.