Abcam, ab99216, Recombinant Human GMFB protein

Size: 100µg / 500µg
Recombinant Human GMFB protein is a Human Full Length protein, in the 1 to 142 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P60983,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
This product was previously labelled as GMF beta

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Glia Maturation Factor Beta (GMFB) is an important regulator in brain development and maintenance. It is also known by the name GMF-b. This protein weighs approximately 17.2 kDa and is expressed in glial cells of the central nervous system as well as other tissues including skin and kidney. By stimulating differentiation and maturation of glial cells GMFB influences central nervous system homeostasis and glial responses to injury.
Biological function summary
GMFB influences numerous cellular processes such as brain maturation and injury repair. It does not form part of a complex but functions independently to exert influence on various targets. GMFB aids in the reorganization of the actin cytoskeleton which is important for cell shape and motility. It regulates neural signaling by interacting with signaling molecules enabling adaptability and cellular communication.
Pathways
GMFB significantly affects neurotrophic and inflammatory pathways. It interacts with proteins like PI3K and AKT to modulate neural survival and plasticity impacting brain health and response to stress. The protein also involves itself in inflammation-related pathways supporting cytokine production and immune responses during injury and infection. Through these interactions GMFB ensures optimal cellular function and organismal health.
GMFB has links to neurodegenerative diseases and gliomas. Abnormal GMFB expression connects with Alzheimer's disease affecting neural health and functionality. In the context of gliomas GMFB influences tumor progression and microenvironment implicating it in tumorigenesis. In these disorders GMFB interacts with proteins such as GFAP and beta-amyloid leading to dysregulation in cellular signaling and pathological developments.