Abcam, ab99221, Anti-Neuropeptide S antibody

Size: 100µL
Rabbit Polyclonal Neuropeptide S antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Neuropeptide S aa 50 to C-terminus.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse,
Applications:ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human Neuropeptide S aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.P0C0P6

Properties and Storage Information:
Form-Liquid, Purity-Whole antiserum, Storage buffer-Preservative: 0.02% Sodium azideConstituents: Whole serum, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Neuropeptide S also called NPS functions as a signaling molecule in the brain influencing arousal alertness and anxiety modulation. This peptide consists of 20 amino acids with an approximate mass of 2 kDa. Expression of NPS occurs mainly in distinct brainstem areas including the locus coeruleus. Neuropeptide S interacts with its specific receptor NPSR1 to exert its effects. Its receptor has widespread distribution not only in the central nervous system but also peripheral tissues.
Biological function summary
Neuropeptide S impacts the brain's response to stress and emotion regulation. It does not form part of a complex rather it binds directly with its receptor to initiate signaling cascades. NPS can enhance arousal and promote wakefulness which affects the sleep-wake cycle and stress response. The activation of NPSR1 by Neuropeptide S also plays a role in reducing anxiety-like behaviors. Through these functions Neuropeptide S influences various behavioral and physiological processes.
Pathways
Neuropeptide S notably contributes to the stress response pathway and the modulation of anxiety. It interacts mainly through the cyclic AMP-protein kinase A (cAMP-PKA) pathway. Neuropeptide S modulates the release of neurotransmitters serotonin and noradrenaline through these signaling processes thereby affecting mood and alertness. These pathways interconnect with those of other neurotransmitters facilitating complex brain functions and responses.
Neuropeptide S has links to anxiety disorders and sleep disturbances. Dysregulation of NPSR1 activity often associates with heightened anxiety suggesting a potential target for therapeutic intervention in anxiety-related conditions. Additionally Neuropeptide S alongside noradrenaline influences the brain's arousal mechanisms connecting to sleep disorders like insomnia. Understanding of the interaction between Neuropeptide S and these pathways provides insights into the development of treatments for these conditions.