Abcam, ab99277, Anti-ORC2 antibody

Size: 100µL
Rabbit Polyclonal ORC2L antibody. Suitable for IHC-P, IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ORC2 aa 1-50.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IHC-P, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ORC2 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.Q13416

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The Origin Recognition Complex Subunit 2 also known as ORC2 is a protein that forms an important part of the origin recognition complex (ORC). ORC2 helps initiate DNA replication by identifying and binding to origins of replication in the DNA. It is a protein weighing approximately 62 kDa and is ubiquitously expressed in various tissues. As a central component of the ORC ORC2 collaborates with other components including ORC1 ORC3 ORC4 ORC5 and ORC6 to establish the loading of the pre-replicative complex essential for the initiation of DNA replication.
Biological function summary
ORC2 significantly contributes to the maintenance of genomic stability by participating in DNA replication origins' identification. As part of the origin recognition complex ORC2 operates in the S phase of the cell cycle to ensure that DNA replicates once and only once per cycle. By binding to replication origins ORC2 plays a pivotal role in the formation and stability of the pre-replication complex. The function of ORC2 is therefore important for the precise timing of replication and avoidance of re-replication within the cell cycle.
Pathways
ORC2 predominantly functions within the DNA replication pathway. ORC2 works alongside other proteins such as Minichromosome Maintenance Complex (MCM) proteins to facilitate the progression and completion of DNA replication. Furthermore ORC2 has connections to the cell cycle regulation pathway coordinating with proteins like Cyclin-Dependent Kinases (CDKs) which ensure that replication is synchronized with other cell-cycle events. This cooperation enables the precise orchestration of replication with cell division.
ORC2 has potential links to certain cancers and developmental disorders. Dysregulation or mutation of ORC2 can lead to genomic instability contributing to the onset of cancers. Additionally its malfunction has associations with Meier-Gorlin syndrome a rare genetic disorder caused by defects in genes associated with ORC. This ties ORC2 to other cancers and developmental disorders-related proteins such as ORC4 and ORC6 which also play significant roles in these processes. Understanding ORC2's function and regulation offers important insights into these diseases' mechanisms and potential therapeutic targets.