Abcam, ab99293, Anti-SGT1/ECD antibody

Size: 100µL
Rabbit Polyclonal SGT1/ECD antibody. Suitable for IP, WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human ECD aa 450-500.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, IPSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human ECD aa 450-500. The exact immunogen used to generate this antibody is proprietary information.O95905

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 6.8 - 7.4Preservative: 0.09% Sodium azideConstituents: Tris buffered saline, 0.1% BSA, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SGT1/ECD also known as SGT1 (Suppressor of G2 allele of SKP1) or ECD (Ectodermal Dysplasia protein) is a regulatory protein with a mass of approximately 36 kDa. It is highly expressed in various eukaryotic cells and tissues. This protein plays an important mechanical role by facilitating the assembly and stabilization of protein complexes. SGT1/ECD acts as a co-chaperone assisting HSP90 in its function which is critical for client protein folding and activity.
Biological function summary
SGT1/ECD participates in the assembly of multi-protein complexes. It is also intertwined with the SCF (SKP1-Cullin1-F-box) ubiquitin ligase complex where it contributes to substrate recognition and proteasomal degradation. Furthermore SGT1/ECD is important in regulating the cell cycle and signal transduction processes involving plant immunity and kinetochore function during chromosome segregation.
Pathways
SGT1/ECD engages in both the plant and animal kingdoms. In plants it plays a role in the resistance (R) gene-mediated signaling pathways and the jasmonic acid pathway where it pairs with chaperones like HSP90. In animals it links with cell cycle pathways affecting proteins such as SKP1 and HSP90. Through these interconnected pathways SGT1/ECD is linked to vital signaling mechanisms impacting cellular responses and stress tolerance.
SGT1/ECD shows connections to cancer and immune response dysregulation. Within cancer biology altered SGT1/ECD expression influences the stability of oncogenic client proteins via HSP90. Additionally in the context of immune disorders it is involved in plant immunity defects where malfunction in SGT1/ECD-mediated pathways can lead to impaired disease resistance. Its associations with proteins like HSP90 and components of the SCF complex highlight its relevance in maintaining cellular homeostasis and proper immune functions.