Abcam, ab99949, Anti-HERC6 antibody

Size: 100µg
Rabbit Polyclonal HERC6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Probable E3 ubiquitin-protein ligase HERC6 aa 100-400.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human Probable E3 ubiquitin-protein ligase HERC6 aa 100-400. The exact immunogen used to generate this antibody is proprietary information.Q8IVU3

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-Preservative: 0.02% Sodium azide, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The protein HERC6 also known as HECT and RLD domain containing E3 ubiquitin protein ligase 6 plays a mechanical role in the ubiquitination process. It is a part of the HERC family of ubiquitin ligases characterized by an E3 ubiquitin-ligase domain. HERC6 has an approximate molecular mass of 119 kDa. This protein is ubiquitously expressed across various tissues with especially high levels found in the spleen lung and testis. Its mechanical role involves tagging proteins for degradation which is an important function in regulating protein levels.
Biological function summary
HERC6 contributes to the cellular antiviral response. It participates in the conjugation of the ubiquitin-like protein ISG15 (interferon-stimulated gene 15) to target proteins a modification known as ISGylation. This function supports its participation in host defense mechanisms against viral infections. As an enzyme HERC6 controls ISGylation events either independently or as part of larger protein complexes influencing various cellular processes.
Pathways
The cellular role of HERC6 intersects with the ISGylation pathway. This process involves several enzymes including the E1-activating ISG15 and E2-conjugating enzymes. Additionally HERC6 has connections to the proteasome degradation pathway where ubiquitination marks proteins for breakdown. This protein works in concert with other components like HERC5 another E3 ligase to facilitate antiviral defense through the modification of viral and host proteins.
HERC6 is associated with conditions involving viral infection and immune response. Its dysfunction can potentially impact the efficiency of the immune defense mechanism making the host more susceptible to viruses like influenza or HIV. As it works closely with ISG15 altered expression or activity of HERC6 or ISG15 could play a role in such viral-related diseases. It may also influence cancer development as disruptions in protein degradation pathways are commonly linked with tumor progression highlighting the need for further research into its pathophysiological roles.