Agilent, 685975-908, AdvanceBio HIC, 4.6 × 100 mm, 3.5 µm

AdvanceBio HIC, 4.6 × 100 mm, 3.5 µm. These hydrophobic interaction chromatography columns are based on fully porous ZORBAX particles and are designed for native mode separations of proteins, mAbs, and ADCs based on hydrophobicity

Specifications:
Brand: AdvanceBio HIC
Hardware: SS
Inner Diameter (ID): 4.6 mm
LC Platform: Stainless Steel
Length: 100 mm
Maximum Temperature: 60 °C
Particle Size: 3.5 µm
Particle Type: Fully Porous
Pore Size: 450 Å
Pressure Rating: 400 bar
Separation Mode: Hydrophobic Interaction (HIC)
Shipping Solvent: Acetonitrile
UNSPSC Code: 41115709
pH Range: 2-8

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The AdvanceBio HIC, 4.6 × 100 mm, 3.5 µm column is specifically engineered for high-resolution hydrophobic interaction chromatography of biomolecules, such as monoclonal antibodies, antibody-drug conjugates, proteins, and other complex biologics. Its 3.5 µm particle size delivers exceptional separation performance and sensitivity, enabling researchers to analyze heterogeneity, aggregation, and subtle post-translational modifications with confidence. The robust stationary phase facilitates reliable retention and efficient recovery of intact proteins under native conditions, minimizing denaturation and loss of activity. This column is ideal for method development, process monitoring, purity assessments, and quality control in biopharmaceutical research and development. It integrates seamlessly with Agilent’s HPLC and UHPLC systems, including the 1260 Infinity II and 1290 Infinity series, as well as with other leading chromatography platforms. AdvanceBio HIC columns are compatible with typical aqueous salt and buffer systems used in hydrophobic interaction studies, supporting reproducible and scalable analytical workflows. For added flexibility, these columns complement other AdvanceBio products for comprehensive protein characterization, such as size exclusion, reversed-phase, and ion exchange columns, making them a reliable tool for demanding analytical challenges in modern bioanalysis laboratories.