Biolegend, 102701, Purified anti-mouse CD38 Antibody, 50μg

CD38 is a 45 kD type II transmembrane glycoprotein also known as T10. It is an ADP-ribosyl hydrolase expressed at variable levels on hematopoietic cells and in some non-hematopoietic tissues (such as brain, muscle, and kidney). In humans, it is expressed at high levels on plasma cells and activated T and B cells, natural killer (NK) lymphocytes, myeloblasts, and erythroblasts. By functioning as both a cyclase and a hydrolase, CD38 mediates lymphocyte activation, adhesion, and the metabolism of cADPR and NAADP. CD31 is the ligand of CD38.
50μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse bone marrow pre-B cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested IHC-F - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Chang CY, et al. 2022. Sci Adv. 8:eabq0615. PubMed Avalos A, et al. 2022. JCI Insight. 7: . PubMed Niss Arfelt K, et al. 2017. Blood. 129:866. PubMed Sereni L, et al. 2018. J Allergy Clin Immunol. 142:1272. PubMed Jackson JW, et al. 2021. Mol Ther Oncolytics. 22:444. PubMed Mrdjen D et al. 2018. Immunity. 48(2):380-395 . PubMed Nabar NR, et al. 2022. Autophagy. 18:204. PubMed De Simone G, et al. 2021. Immunity. :. PubMed Gubin MM, et al. 2018. Cell. 175:1014. PubMed Jiao S, et al. 2020. Cell. 179(5):1177-1190.e13.. PubMed Pushalkar S, et al. 2018. Cancer Discov. 0.613194444. PubMed Lee A, et al. 2022. Nat Commun. 13:549. PubMed
RRID: AB_312923 (BioLegend Cat. No. 102702)
Structure: ADP-ribosyl hydrolase, 42 kD
Distribution: B cells, NK cells, T cell subset, brain, muscle, kidney
Function: Regulation of cellular activation/proliferation, adhesion, metabolism of cADPR and NAADP
Ligand/Receptor: CD31, hyaluronic acid
Antigen References: 1. Barclay AN, et al. 1997. The Leukocyte Antigen FactsBook Academic Press. 2. Shubinsky G, et al. 1997. Immunity 7:315. 3. Cesano A, et al. 1998. J. Immunol. 160:1106. 4. Cockayne DA, et al. 1998. Blood 92:1324.
Gene ID: 12494
UniProt: View information about CD38 on UniProt.org
Clone: 90
Regulatory Status: RUO
Other Names: T10
Isotype: Rat IgG2a, κ