Biolegend, 134401, Purified anti-mouse lymphotoxin beta receptor (LTβR) Antibody, 25μg

LTβR is a type I transmembrane glycoprotein and member of the TNF receptor superfamily. It is a 61 KDa receptor for the mouse LTα1β2 and LIGHT. Northern blot analysis of tissues from adult mice showed that expression levels of LTβR mRNA were strong in lung, liver, and kidney, moderate in heart and testes, but weak in brain, thymus, spleen, and lymph nodes. It was reported that LTβR is expressed on stromal cells, monocytes, and certain embryonic epithelial layers. LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: E.coli expressed extracellular domain of mouse lymphotoxin beta receptor
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Product Citations: Simmons S et al. 2019. Elife. 8 pii: e41239. PubMed
RRID: AB_1659177 (BioLegend Cat. No. 134402)
Distribution: Expressed on stromal cells, monocytes, and certain embryonic epithelial layers.
Function: LTβR is involved in peripheral lymphoid tissue organogenesis and function. The LTα/LTβR receptor system may also have some function in early embryogenesis.
Ligand/Receptor: LTα1β2 and LIGHT
Cell Type: Embryonic Stem Cells, Epithelial cells, Monocytes
Biology Area: Immunology, Stem Cells
Molecular Family: Adhesion Molecules, Cytokine/Chemokine Receptors
Antigen References: 1. Force WR, et al. 1995. J. Immunol. 155:5280 2. Tamada K, et al. 2000. J. Immunol. 164:4105 3. Browing JL, et al. 1997. J. Immunol. 159:3288 4. Futterer A, et al. 1998. Immunity 9:59 5. Nakamura T, et al. 1995. Genomics 30:312 6. Crowe P, et al. 1996. Science 264:707 7. Dejardin E, et al. Immunity 2002. 17(4):525
Gene ID: 17000
UniProt: View information about LT-betaR on UniProt.org
Clone: 5G11
Regulatory Status: RUO
Other Names: LTbR, TNFRIII, TNF receptor-related protein (TNFRrp)
Isotype: Rat IgG2a, κ