Biolegend, 150329, PE/Dazzle™ 594 anti-mouse CD198 (CCR8) Antibody, 25μg

C-C chemokine receptor type 8 (CCR8) CD198, is a 41 kD G-protein coupled receptor with 7 transmembrane regions. CCR8 is expressed by a subset of thymocytes, Tregs, NKT and Th2-polarized cells, a subset of macrophages, monocytes, and monocyte-derived dendritic cells. CCR8 mediates chemotaxis toward its ligand CCL1, and is involved in apoptosis of thymocytes.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse CD198 (CCR8)-transfected cells
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PE/Dazzle™ 594 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * PE/Dazzle™ 594 has a maximum excitation of 566 nm and a maximum emission of 610 nm.
Excitation Laser: Blue Laser (488 nm)Green Laser (532 nm)/Yellow-Green Laser (561 nm)
RRID: AB_2927807 (BioLegend Cat. No. 150329) AB_2927807 (BioLegend Cat. No. 150330)
Structure: G-protein coupled receptor, 7 transmembrane regions, 41 kD.
Distribution: Thymocytes, Tregs, NKT and Th2-polarized cells, subset of macrophages, monocytes and monocyte-derived dendritic cells.
Function: Chemotaxis, involved in thymocyte apoptosis
Ligand/Receptor: CCL1 (SCY1,TCA-3)
Cell Type: Dendritic cells, Macrophages, Monocytes, NKT cells, Th2, Thymocytes, Tregs
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Coghill JM, et al. 2013. Blood. 122:825. 2. Islam SA, et al. 2011. Nat. Immunol. 12:167. 3. Hoshino A, et al. 2007. J. Immunol. 178:5296. 3. Qu C, et al. 2004. J. Exp. Med. 200:1231.
Gene ID: 12776
UniProt: View information about CD198 on UniProt.org
Clone: SA214G2
Regulatory Status: RUO
Other Names: CDw198, C-C chemokine receptor type 8, CKR-8, CC-CKR-8, Ter1
Isotype: Rat IgG2b, κ