Biolegend, 152506, FITC anti-mouse CD191 (CCR1) Antibody, 100μg

CD191, also known as CCR1, is a seven transmembrane G protein coupled receptor. It is involved in protecting the host from inflammatory responses and viral/parasite invasion, ligands include macrophage inflammatory protein 1 alpha (MIP-1 alpha, ), regulated on activation normal T expressed and secreted protein (RANTES, CCL5), monocyte chemoattractant protein 3 (MCP-3, CCL7), and myeloid progenitor inhibitory factor-1 (MPIF-1, CCL23).
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse CCR1-transfectants.
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with FITC under optimal conditions.
Concentration: 0.5 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤1.0 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Blue Laser (488 nm)
Product Citations: Palakurthi B, et al. 2023. Nat Commun. 14:2109. PubMed Ajina R, et al. 2021. Cancer Immunol Res. 9:386. PubMed
RRID: AB_2687210 (BioLegend Cat. No. 152505) AB_2687211 (BioLegend Cat. No. 152506)
Structure: 41KD, seven transmembrane protein.
Distribution: Macrophages, monocytes, neutrophils and eosinophils.
Function: Regulating migration of cells in response to CCL3, CCL5, CCL7 and CCL23.
Ligand/Receptor: CCL3, CCL5, CCL7 and CCL23.
Cell Type: Eosinophils, Macrophages, Monocytes, Neutrophils
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: 1. Lionakis MS, et al. 2012. PLoS Pathog. 8:e1002865. 2. Gilliland CT, et al. 2013. J. Biol. Chem. 288:32194. 3. Gong X, et al. 1997. J. Biol. Chem. 272:11682. 4. Daugherty BL, Springer MS. 1997. Genomics. 41:294. 5. Pakianathan DR, et al. 1997. Biochemistry 36:9642.
Gene ID: 12768
UniProt: View information about CD191 on UniProt.org
Clone: S15040E
Regulatory Status: RUO
Other Names: CKR1, CKR-1, HM145, CMKBR1, MIP1aR, SCYAR1
Isotype: Rat IgG2b, κ