Biolegend, 155931, PerCP/Fire™ 806 anti-mouse CD183 (CXCR3) Antibody, 25μg

CD183, also known as CXCR3, is a member of the C-X-C chemokine family, characterized by a pair of cysteine residues separated by a single amino acid. CXCR3 is a 38 kD seven pass transmembrane receptor coupled to G-protein. It mediates Ca 2+ mobilization and chemotaxis in response to C-X-C chemokines, such as IP10 (CXCL10), MIG (CXCL9), I-TAC (CXCL11) and PF4 (CXCL4). CXCR3 is expressed primarily on activiated T lymphocytes, NK cells, and some epithelial cells and endothelial cells. It is not expressed on B cells, monocytes, or granulocytes.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse CXCR3-transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with PerCP/Fire™ 806 under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * PerCP/Fire™ 806 has a maximum excitation of 478 nm and a maximum emission of 806 nm.
Excitation Laser: Blue Laser (488 nm)
RRID: AB_3675006 (BioLegend Cat. No. 155931) AB_3675006 (BioLegend Cat. No. 155932)
Structure: 38 kD seven pass transmembrane receptor coupled to G-protein.
Distribution: T cells, plasmacytoid dendritic cells, GM-CSF activated CD34+ hematopoietic progenitors
Function: Essential in T cell recruitment to sites of inflammation
Ligand/Receptor: CXCL10, CXCL9, CXCL11 and CXCL4
Cell Type: Dendritic cells, Hematopoietic stem and progenitors, T cells
Biology Area: Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: Farber JM. 1997. J. Leukoc. Biol. 61(3):\246-57. Bonecchi R, et al. 1998. J. Exp. Med. 187(1):129-34. Aota K, et al. 2018. J. Oral. Pathol. Med. 12756. Kim B, et al. 2018. Data. Brief. 18:518-522. Saahene RO, et al. 2018. Cancer Biother. Radiopharm. 2450.
Gene ID: 12766
UniProt: View information about CD183 on UniProt.org
Clone: S18001A
Regulatory Status: RUO
Other Names: CXCR3, G protein-coupled receptor 9 (GPR9), CKR-L2, IP10 receptor (IP10-R), Mig receptor (Mig-R)
Isotype: Rat IgG2b, κ