Biolegend, 158706, APC anti-mouse CD129 (IL-9R) Antibody, 100μg

CD129 is the ligand binding subunit of IL-9 receptor (IL-9R or IL-9Rα). It is a type I transmembrance glycoprotein belonging to the hematopoientin receptor superfamily. The signal transducing subunit is common gamma chain (γc, CD132), which is shared with receptors for IL-2, IL-4, IL-7, and IL-21. The mouse IL-9R has 468aa and is about 52.2kD. Besides modulating immune response, signals through IL-9 and IL-9R are also invoved in allergy and inflammatory disorders.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Mouse IL-9R transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
Product Citations: Pajulas, A. et al. 2023. Mucosal Immunology. 16(4), 432-445. PubMed
RRID: AB_2832564 (BioLegend Cat. No. 158705) AB_2860744 (BioLegend Cat. No. 158706)
Structure: Type I transmemberane glycoprotein; WSXWS motif
Distribution: Subset of B cells, mast cells
Function: Binding IL-9; activate JAK-STAT signaling
Interaction: Common gamma chain (CD132)
Ligand/Receptor: IL-9
Cell Type: B cells, Eosinophils, Mast cells, T cells, Thymocytes
Biology Area: Adaptive Immunity, Immuno-Oncology, Immunology
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, Growth Factors
Antigen References: Druez C, et al. 1990. J Immunol. 145:2494-9. Renauld JC, et al. 1992. Proc Natl Acad Sci USA. 89:5690-4. Takatsuka S, et al. 2018. Nat Immunol. 19:1025-1034.
Gene ID: 16199
UniProt: View information about CD129 on UniProt.org
Clone: S18011E
Regulatory Status: RUO
Other Names: Interleukin-9 receptor, IL-9 receptor, IL-9R, IL9Rα
Isotype: Rat IgG2a, κ