Biolegend, 160707, KIRAVIA Blue 520™ anti-mouse IL-31 Antibody, 25μg

IL-31, mainly produced by activated CD4+ T cells, is a helical cytokine belonging to the gp130/IL-6 cytokine family. IL-31 is closely related in structure to IL-6, IL-11, and IL-27. Binding of IL-31 to its receptor activates JAK/STAT, PI3K/AKT, and MAPK pathways. IL-31 acts on a broad range of immune and non-immune cells and thus possesses potential pleiotropic physiological functions, such as regulating hematopoiesis and immune response. Transgenic mice overexpressing IL-31 developed severe dermatitis, indicating that IL-31 is involved in skin immunity.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Recombinant mouse IL-31
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with KIRAVIA Blue 520™ under optimal conditions.
Concentration: 0.2 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: ICFC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by intracellular immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * KIRAVIA Blue 520™ has an excitation maximum of 495 nm, and a maximum emission of 520 nm. KIRAVIA Blue™ 520 is a trademark of Sony. This product is subject to proprietary rights of Sony and is made and sold under license from Sony Corporation. This product is covered by U.S. Patent(s), pending patent applications and foreign equivalents.Sony and the Sony logo are registered trademarks of Sony Corporation.
Excitation Laser: Blue Laser (488 nm)
RRID: AB_2910332 (BioLegend Cat. No. 160707) AB_2910332 (BioLegend Cat. No. 160708)
Structure: Member of IL-6 family of cytokines
Distribution: Subset of CD4 T cells
Ligand/Receptor: IL-31Ra/OSMR
Cell Type: Lymphocytes, T cells, Th2, Thymocytes
Biology Area: Adaptive Immunity, Immunology, Innate Immunity
Molecular Family: Cytokines/Chemokines
Antigen References: McCandless EE, et al. 2014. Vet. Immunol. Immunopathol. 157:42. Arai I, et al. 2013. Exp. Dermatol. 22:669. Dai X, et al. 2013. PLoS One. 8:e67666. Stott B, et al. 2013. J. Allergy Clin. Immunol. 132:446. Hartmann K, et al. 2013. J. Allergy Clin. Immunol. 132:232. Baron JM and Lüscher B. 2012. Acta. Derm. Venereol. 92:5
Gene ID: 76399
UniProt: View information about IL-31 on UniProt.org
Clone: W17037B
Regulatory Status: RUO
Other Names: Interleukin-31
Isotype: Rat IgG2a, κ