Biolegend, 163103, Alexa Fluor® 647 anti-mouse CD36L Antibody, 25μg

Scavenger receptor class B type I (SCARB1), also known as CD36L1, is a member of the scavenger receptor family. It is an integral membrane protein and function as HDL receptor expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a mechanism distinct from the classic LDL receptor pathway. Its primary function is facilitating reverse cholesterol transport by transferring cholesterol esters of high-density lipoproteins (HDLs) into the liver. This function serves to lower the risk of development of atherosclerosis. SCARB1 is also able to bind to other lipoproteins such as LDL, OxLDL, and VLDL. SCARB1 is also likely to be involved in pathogen recognition through its recognition of mycobacteria and other viral proteins and regulates vitamin E levels in the tissue.
25μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography and conjugated with Alexa Fluor® 647 under optimal conditions.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: IHC-F - Quality tested FC - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunohistochemical staining on frozen tissue sections. For immunohistochemistry, a concentration of 5.0 µg/mL is suggested. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application. * Alexa Fluor® 647 has a maximum emission of 668 nm when it is excited at 633 nm / 635 nm. Alexa Fluor® and Pacific Blue™ are trademarks of Life Technologies Corporation.View full statement regarding label licenses
Excitation Laser: Red Laser (633 nm)
Application References(PubMed link indicates BioLegend citation): 1. Tsugita M. et al. 2017. Cell Rep. 18:1298.
RRID: AB_3105988 (BioLegend Cat. No. 163103) AB_3105988 (BioLegend Cat. No. 163104)
Structure: Integral membrane glycoprotein
Distribution: Liver and nonplacental steroidogenic tissues
Function: Involved in the uptake of high density lipoproteins (HDL), phagocytosis of apoptotic cells, and pathogen recognition.
Ligand/Receptor: Phosphatidylserine, HDL, apoB-containing lipoproteins, LDL, vitamin E
Cell Type: Macrophages, Monocytes, Platelets
Biology Area: Cell Biology, Immunology
Molecular Family: CD Molecules
Antigen References: Acton S, et al. 1996. Science. 5248:518. Rigotti A, et al. 2003. Endocr Rev. 24:357. Valacchi G, et al. 2011. Ann N Y Acad Sci. 1229:E1-7. Scarselli E, et al. 2002. EMBO J. 21:5017. Mardones P, et al. 2002. J Nutr. 132:443.
Gene ID: 20778
UniProt: View information about CD36L on UniProt.org
Clone: AOB-1
Regulatory Status: RUO
Other Names: SCARB1, SR-BI
Isotype: Rat IgG2a, κ