Biolegend, 163902, Purified anti-mouse CD182 (CXCR2) Antibody, 100μg

CD182, also known as CXCR2, is a G-protein coupled receptor with 7 transmembrane regions that is involved in chemotaxis, neutrophil activation and angiogenesis. CXCR2 is expressed by neutrophils, basophils, subset of T cells, monocytes, macrophages, NK and NKT cells. Its ligands are CXCL1, CXCL2, CXCL3 and CXCL5.
100μg
Verified Reactivity: Mouse
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Pre-B cell transfected with mCXCR2
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested Block - Verified
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: Clone 3F10-B3 blocks the chemotaxis towards CXCR2 ligands.
RRID: AB_2924493 (BioLegend Cat. No. 163902)
Structure: G-protein coupled receptor, 7 transmembrane regions.
Distribution: Neutrophils, basophils, subset of T cells, monocytes, macrophages, and natural killer cells (NK)
Function: Chemotaxis, neutrophil activation, and angiogenesis
Ligand/Receptor: CXCL1, CXCL2, CXCL3, and CXCL5
Cell Type: Neutrophils
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience
Molecular Family: CD Molecules, Cytokine/Chemokine Receptors, GPCR
Antigen References: Spaan AN, et al. 2014. Nat Commun. 5:5438. Natsuaki Y, et al. 2014. Nat. Immunol. 11:1064-9. Hsieh CY, et al. 2014. J Immunol. 193:3693-703.
Gene ID: 12765
UniProt: View information about CD182 on UniProt.org
Clone: 3F10-B3
Regulatory Status: RUO
Other Names: IL-8RB, GRO/MGSA, Cmkar2
Isotype: Mouse IgG2c, κ