Biolegend, 164102, Purified anti-mouse CD170 (Siglec-F) Recombinant Antibody, 100μg

CD170, also known as Siglec-F, Siglec-5, is a member of the Sialic acid-binding Ig-like lectin family, type I single pass transmembrane protein, with 4 extracellular Ig-like domains and 2 ITIM motifs in the cytoplasmic domain; preferentially binds [alpha]-2,3-linked sialic acid. Siglec F is expressed in eosinophils, alveolar macrophages and intestinal microfold (M) cells and induces apoptosis of the lung eosinophils during allergic asthma.
100μg
Verified Reactivity: Mouse
Antibody Type: Recombinant
Host Species: Rat
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
Application Notes: This recombinant antibody clone is derived from clone S17007L.
RRID: AB_2922500 (BioLegend Cat. No. 164102)
Structure: Member of the immunoglobulin superfamily, single pass transmembrane protein, forms a 140 kD dimer; cytoplasmic domain contains two ITIM motifs
Distribution: Granulocytes, Monocytes, Macrophages, Lymphocytes, Dendritic cells, B cells, eosinophils.
Function: Inhibitory receptor, cell adhesion
Ligand/Receptor: α2,3- and α2,6-linked sialic acid.
Gene ID: 8778
UniProt: View information about CD170 on UniProt.org
Clone: QA20A11
Regulatory Status: RUO
Other Names: OBBP2, CD33L2, OB-BP2
Isotype: Rat IgG1, κ