Biolegend, 250808, APC anti-rat CD335 (NKp46) Antibody, 100μg

CD335, also known as NKp46, is a glycoprotein of the natural cytotoxicity receptor (NCR) family with 2 Ig-like domains and a short cytoplasmic tail. CD335 expression is restricted to NK cells and a subset of NKT cells; it's not expressed in CD1d-restricted NKT cells. NKp46 functions as a cytotoxicity triggering receptor.
100μg
Verified Reactivity: Rat
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: Rat NKp46 ectodomain recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide.
Preparation: The antibody was purified by affinity chromatography and conjugated with APC under optimal conditions.
Concentration: 0.2 mg/ml
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤0.25 µg per million cells in 100 µl volume. It is recommended that the reagent be titrated for optimal performance for each application.
Excitation Laser: Red Laser (633 nm)
RRID: AB_2734244 (BioLegend Cat. No. 250807) AB_2734245 (BioLegend Cat. No. 250808)
Structure: Single-pass type I membrane protein, 46 kD; belongs to the natural cytotoxicity receptor (NCR) family; contains 2 Ig-like (immunoglobulin-like) domains.
Distribution: Mature and immature NK cells, subset of NKT cells, but not on CD1d-restricted NKT cells.
Function: NK cells activation
Ligand/Receptor: Viral hemagglutinins, heparan sulfate proteoglycans
Cell Type: NK cells, NKT cells
Biology Area: Immunology, Innate Immunity
Molecular Family: CD Molecules
Antigen References: Westgaard IH, et al. 2004. J. Leuko. Biol. 76:1200. Falco M, et al. 1999. Immunol. Lett. 68:411. Caligiuri MA. 2008. Blood. 112:461.
Gene ID: 117547
UniProt: View information about CD335 on UniProt.org
Clone: WEN23
Regulatory Status: RUO
Other Names: NCR1, NKP46, LY94
Isotype: Mouse IgG1, κ