Biolegend, 301502, Purified anti-human CD112R (PVRIG) Antibody, 100μg

CD112R gene encodes a single transmembrane protein consisting of a single extracellular IgV domain. Its long intracellular domain contains two tyrosine residues, one of which is within an ITIM-like motif. CD112R was initially named PVRIG for the homology observed between its second exon and the variable immunoglobulin domain of the polio virus receptor (PVR/CD155) and polio virus receptor-like (PVRL) genes. CD112R is a cell surface receptor for CD112/Nectin-2, it compete against CD226 in binding to CD112. Following interaction with CD112, CD112R inhibits T-cell proliferation and the disruption of interaction between CD112R and CD112 enhances T cell response. Published studies suggest that CD112R is a novel co-inhibitory receptor, or a checkpoint molecule, that suppressed TCR medicated signal.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Rat
Immunogen: Human CD112R transfectants
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_2860764 (BioLegend Cat. No. 301502)
Structure: IgV domain; ITIM motif
Distribution: T cells, NK cells
Function: Cell surface receptor for CD112, negative regulator of T cell response
Ligand/Receptor: CD112 (Nectin-2)
Cell Type: Leukocytes, Lymphocytes, NK cells, T cells
Biology Area: Adaptive Immunity, Immuno-Oncology, Immunology, Inhibitory Molecules
Molecular Family: Immune Checkpoint Receptors
Antigen References: Xu F, et al. 2017. Cancer Immunol. Immunother. 66:1367-1375. Zhu Y, et al. 2016. J. Exp. Med. 213(2):167-76.
Gene ID: 79037
UniProt: View information about CD112R on UniProt.org
Clone: W16216D
Regulatory Status: RUO
Other Names: Poliovirus receptor-related immunoglobulin domain containing protein, PVRIG, C7orf15, CD112 receptor
Isotype: Rat IgG2a, κ