Biolegend, 312405, Purified anti-human CD120b Antibody, 100μg

CD120b, also known as TNFRII or TNFRSF1B, belongs to the TNF receptor superfamily and can interact with ligands TNF-α and TNF-β (also known as LT-α). It is a 75 kD type I transmembrane protein expressed on lymphocytes, monocytes, and granulocytes. When present in a heterocomplex with CD120a, it induces the recruitment of anti-apoptotic molecules, c-IAP1 and c-IAP2, which possess E3 ubiquitin ligase activity. Mutations in CD120b are associated with TNF-associated periodic syndrome (TRAPS) or periodic fever syndrome.
100μg
Verified Reactivity: Human
Antibody Type: Monoclonal
Host Species: Mouse
Immunogen: CD120b recombinant protein
Formulation: Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide
Preparation: The antibody was purified by affinity chromatography.
Concentration: 0.5 mg/mL
Storage & Handling: The antibody solution should be stored undiluted between 2°C and 8°C.
Application: FC - Quality tested
Recommended Usage: Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.5 µg per million cells in 100 µL volume. It is recommended that the reagent be titrated for optimal performance for each application.
RRID: AB_3698968 (BioLegend Cat. No. 312405)
Structure: 75 kD, type I transmembrane protein, member of the TNF-receptor superfamily, forms a heterocomplex with TNFRI
Distribution: Expressed on cells of hematopoietic lineage including monocytes, lymphocytes, and granulocytes
Function: When complexed with TNFRI, recruits anti-apoptotic molecules c-IAP1 and c-IAP2 which possess E3 ubiquitin ligase activity; cysteine rich extracellular region
Interaction: Interacts with TTRAP and TRAF2
Ligand/Receptor: TNF-α and TNF-β (LT-α)
Cell Type: Granulocytes, Lymphocytes, Monocytes
Biology Area: Cell Biology, Immunology, Innate Immunity, Neuroinflammation, Neuroscience, Transcription Factors
Molecular Family: CD Molecules
Antigen References: Andrews JS, et al. 1990. J Immunol. 144:2582-91. Nophar Y, et al. 1990. EMBO J. 9:3269-78. Kohno T, et al. 1990. Proc Natl Acad Sci USA. 87:8331. Tartaglia LA, et al. 1991. Proc Natl Acad. Sci USA. 88:9292. Hijdra D, et al. 2012. J Inflamm (Lond). 9:38. Chen X, et al. 2013. J Immunol. 190:1076-84.
Gene ID: 7133
UniProt: View information about CD120b on UniProt.org
Clone: A22092I
Regulatory Status: RUO
Other Names: TNFRSF1B, p75, p75TNFR, TNFR2, TNFR80, TBPII
Isotype: Mouse IgG2b, κ